Mutation of H63 and its catalytic affect on the methionine aminopeptidase from Escherichia coli
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منابع مشابه
Mutation of H63 and its catalytic affect on the methionine aminopeptidase from Escherichia coli.
In order to gain insight into the mechanistic role of a flexible exterior loop near the active site, made up of Y62, H63, G64, and Y65, that has been proposed to play an important role in substrate binding and recognition in the methionyl aminopeptidase from Escherichia coli (EcMetAP-I), the H63A enzyme was prepared. Mutation of H63 to alanine does not affect the ability of the enzyme to bind d...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
سال: 2009
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2008.09.012